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Polygala XT – 180 Veg Caps



  • Memory
  • Positive Mood
  • Focus & Motivation
  • Enhanced Neuroplasticity
  • Improved Cognitive Function
  • Improved Sense of Well-Being
  • Improved Learning & Executive Function
  • Relaxation & Improved Response to Stress
  • Restful & Restorative Sleep
  • Increases in BDNF and NGF Levels
  • Skin, Respiratory, & Immune Health Support

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Memory, Learning, Positive Mood, & More
Nootropic, Longevity, & Healthy Aging 

100 mg. Polygala per capsule
180 veg caps per bottle

Polygala tenuifolia is commonly used for a wide variety of nootropic benefits and common user feedback includes what many users describe as a unique mentally stimulating yet calming sensation.

Polygala is unique in that it helps to improve cognitive function by helping to optimise neurotransmitter levels while also increasing neuroplasticity. These combined benefits help promote improved focus, motivation, memory, and more.

Polygala XT Highlights/Supports:

  • Memory
  • Positive Mood
  • Focus & Motivation
  • Enhanced Neuroplasticity
  • Improved Cognitive Function
  • Improved Sense of Well-Being
  • Improved Learning & Executive Function
  • Relaxation & Improved Response to Stress
  • Restful & Restorative Sleep
  • Increases in BDNF and NGF Levels
  • Skin, Respiratory, & Immune Health Support
  • Nootropic, Longevity, & Healthy Aging Support


Calm, Alert, & Focused – the Polygala XT Experience 


The ‘Feel’ of Polygala XT

Common user feedback on Polygala includes users experiencing a stimulating yet calming sensation.

It is very unique to experience both of those benefits from one ingredient because this would normally be achieved by combining more than one ingredient or supplement, yet Polygala does it all on its own for many people.

To make things even more interesting is that even though it is stimulating for some people, Polygala may also support improved sleep quality, as many people say that the calming effects seem to outlast the stimulating effects which makes it good for those looking for mental stimulation and mood support.

Experiential feedback from users reports that the calming yet stimulating effects of Polygala supports improvements in focus and cognition without some of the negative drawbacks that some people experience when taking high amounts of caffeine or other stimulants.

What is Polygala tenuifolia?

Polygala tenuifolia is commonly used for a variety of nootropic, longevity, and healthy aging benefits such as supporting improved memory, positive mood, improved learning, and much more.

Polygala tenuifolia, also known as Yuan Zhi, has a long history of use in Traditional Chinese Medicine (TCM). It is one of the 50 fundamental herbs of TCM and is one of the most commonly used herbs in TCM to support cognitive health, to combat forgetfulness, and to support cognitive performance during aging.

Polygala is a nootropic, adaptogen, and antioxidant and produces powerful compounds within its root system including tenuigenin, tenuifolin, yuanzhi-1, tenuifolisides, and tenuifolioses.

What Makes Polygala So Unique and Special?

Polygala is widely used for its nootropic, neuroprotective, and healthy aging properties and is commonly used to support improved memory, positive mood, improved learning, and much more.

It is considered by many to be one of the most powerful and noticeable herbal extracts in the sense that it works for almost everyone who tries it.

Most plant extracts usually have one or two primary effects. Polygala is different because it has such a wide range of potential benefits, making it a very unique and versatile ingredient.

What does 20:1 Extract mean?

SNS Polygala XT contains a potent 20:1 Polygala tenuifolia root extract. This means that 20 parts of the root are used to create 1 part of the extract. This concentrates the active compounds so less of the herb is needed. Basically, a lot more potency at a lower dose and less capsules per day.

Let’s Examine the Potential Benefits:

Polygala has a wide variety of cognitive and other potential benefits.

Many of these benefits may overlap one another or fall into more than one category below, so there may be parts of this next section where certain benefits are listed in more than one place in an effort to be thorough and make it easier to read and understand.

Neuroplasticity, BDNF, and NGF

In the world of natural nootropics, supporting greater neuroplasticity is a highly sought after benefit.

Enhancing neuroplasticity can help improve cognitive health, memory, and promote a positive mood.

Studies have found that Polygala Tenuifolia may help support neuroplasticity.

Neuroplasticity is the process by which our brains can adapt, grow, and change, which is a critical process for various cognitive functions since they are dependent on sufficient levels of neuroplasticity.

Neuroplasticity is the foundation of memory and memories, as our memory and memories are believed to be stored by neuron connections that are physically changing. These changes are dependent on neuroplasticity.

Two of the largest regulators for neuroplasticity are brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF). Research has shown that by increasing either one of these, neuroplasticity can be significantly increased.

Many researchers believe that Polygala elevates both BDNF and NGF levels, and by doing so may help to promote overall brain health and support cognitive function.

A Calmer, More Balanced, & Positive Mood

Polygala may help support a calmer, more balanced, and positive mood.

Polygala supports positive mood and improved sense of well-being through its role in enhancing levels of neurotransmitters such as serotonin, dopamine, and norepinephrine.

Also, by supporting increased neuroplasticity, Polygala may have long-term mood promoting benefits.

Neuroplasticity is a very important regulator of mood. Negative and poor mood has been linked to atrophy in the hippocampus and it has been shown that neuroplasticity enhancers may help reverse hippocampal atrophy, and in doing so may help promote positive mood.

Polygala may also help increase levels of key neurotransmitters such as serotonin, dopamine, and norepinephrine via its Yuanzhi-1 content, which is a unique triterpenoid saponin that inhibits the reuptake of these monoamine neurotransmitters. These three neurotransmitters each play an important role in maintaining a positive mood and are highly involved in focus and motivation.

Focus & Motivation

Polygala may help promote mental focus and motivation.

Staying focused and motivated can be a big challenge in today’s world, especially with all of the stressors and distractions that we face in day to day life.

For those of us who need to be able to focus better – whether it be for studying, at work, in the gym, or in other aspects of day to day life – Polygala may help gently push serotonin, dopamine, and norepinephrine levels in the right direction to help support enhanced levels of focus, motivation, & have an energizing effect that most people describe as a non-stimulating, feel good type of mental energy.

A very unique aspect of Polygala is that it can be both calming and stimulating, which is just what a lot of people need to help them feel less stressed while having a calm, clear, motivated type of feeling.


Polygala tenuifolia has been shown to support memory in both human and animal studies.

In a clinical trial on 48 healthy individuals, Polygala Tenuifolia root extract improved spatial and verbal memory. Those who received it also made less errors and scored better on a test measuring working memory.

In studies on mice, Polygala tenuifolia extract improved both spatial and non-spatial memory in aged mice. It also improved short term memory in mice with drug-induced memory impairment.

Polygala is thought to support memory by:

  • Supporting an increase in neuroplasticity.
  • Increasing BDNF and NGF levels in the brain.
  • Inhibiting the acetylcholinesterase enzyme, which reduces the breakdown of acetylcholine.
  • Promoting the growth of new neurons in the hippocampus (important for the formation of new memories).

More research and clinical studies on larger populations are needed to confirm these preliminary findings, but the initial research indicates very exciting potential benefits.

Cognitive Health & Neuroprotective Benefits

Polygala has some very interesting and exciting potential benefits for supporting improved cognitive health by helping optimize neurotransmitter levels while also increasing neuroplasticity.

Research suggests that Polygala may have neuroprotective properties and support repair processes and molecules, such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF).

Research has also shown that Polygala has adaptogen-like properties and may help to promote healthy stress levels while simultaneously supporting optimal cognitive function.

In one clinical trial on 53 elderly subjects, Polygala tenuifolia extract was shown to enhance cognitive function.

Polygala, by helping to optimize neurotransmitter levels, enhancing neuroplasticity, and balancing neuronal oxidation and inflammation, may help protect the brain from various stressors. This makes it a great choice for overall brain health, especially when considering long term supplementation.

Spatial Awareness & Organization

The first question that most people will have is what does this mean?

Organization, or the ability to be organized, is something that most people will know what it means, and that most of us can use all the help with that we can get.

Spatial awareness, simply put, is your ability to understand your body’s position in relation to your surroundings. It can have an impact on everything from picking up a book, how you perform in various sports, to influencing how you react to and navigate in social settings.

Spatial awareness allows us to be conscious of the things in our environment, as well as our position relative to them. It is important in our day to day life in a lot of ways that we may not realize.

A couple of examples of spatial awareness:

  • Location – spatial awareness gives context to the location of objects.
  • Movement – spatial awareness helps you know how people and objects move through the environment and can help you navigate your surroundings.
  • Social Situations – spatial awareness can affect social functions like the proper maintenance of personal space.
  • Reading & Writing – spatial awareness and understanding is important for understanding sentence structure and grammar.
  • Math – spatial awareness can be important for understanding some mathematical concepts, such as geometry and arranging numbers.

Physical activity and sports, especially contact sports, involve spatial awareness.

Human trials suggest that Polygala tenuifolia may help promote both spatial awareness and organization.

Improved Sleep Quality

Anecdotal feedback on Polygala tenuifolia is that it helps improve sleep quality.

Polygala is described as being mentally stimulating yet calming, and many people report that the calming effects significantly outlast the stimulating effects.

It has been shown that one of the active constituents in Polygala tenuifolia root, tenuifolin, may help improve sleep quality and is also believed to be responsible for a lot of the calming effects associated with Polygala tenuifolia. The effects of tenuifolin appear to be long lasting, which helps explain why many users find the calming effects of Polygala to be long lasting.

A significant note about improved sleep quality is that various studies have shown that poor sleep quality and sleep deprivation can greatly decrease focus and alertness so it’s possible that by helping improve sleep quality, that may help enhance Polygala’s mental alertness and focus benefits.


Polygala tenuifolia and its constituents have been shown to reduce the production of inflammatory cytokines TNF-alpha, IL-1beta, and the master regulator of inflammation NF-kB in white blood cells.

Dermatitis (Eczema)

Dermatitis, also known as eczema, and stress create a vicious cycle as stress exacerbates dermatitis and dermatitis can elicit more stress and anxiety.

Polygala has been shown to reduce stress reduced dermatitis in animal studies. More research is needed in humans before a definitive conclusion can be made, but animal studies have shown remarkable improvements thus far.

How to take Polygala XT

The research on Polygala tenuifolia indicates the effective dose to be 100 mg. three times per day.

Each capsule of Polygala XT contains 100 mg. per capsule.

Sublingual Use:

Some people may prefer to take Polygala Tenuifolia sublingually for more immediate and potent effects and some individuals report it to be more stimulating and focus enhancing when taken in this manner.

For those that desire to take Polygala XT sublingually, empty the contents of one capsule under the tongue and hold under the tongue for approximately one minute before washing it down.

Stacking & Synergy

Polygala XT can be stacked with Focus XT, Stress & Anxiety Support, Mood Support XT, KannaEase, Sabroxy XT, Huperzine A XT,  and/or a wide variety of other SNS products to help you reach your individual goals.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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