BASIS – 120 Veg Capsules

Description

Lean Muscle Growth Stimulator
Natural Anabolic Recomposition Catalyst
Lean Muscle, Strength, Fat Loss, & More

 

BASIS takes a very unique approach to helping you build muscle.

BASIS supports muscle building and fat loss through many of the more well-known pathways but goes a huge step further by supporting the enhancement of specific Bone Morphogenetic Protein (BMP) levels.

BASIS is an ultra-potent natural anabolic recomposition catalyst that contains 12 active ingredients including 7 branded ingredients and is designed to support an increase in the signaling, expression, and levels of specific Bone Morphogenetic Proteins (BMP’s) in order to help you build lean muscle, increase strength, enhance recovery, and improve fat loss.

Target building muscle and losing fat from a new angle to get new anabolic results.

BASIS Highlights/Supports:

• Lean Muscle Gains
• Hardcore Strength Gains
• Improved Fat Loss
• Increased Muscle Fullness
• Joint & Bone Health Support
• Natural Anabolic Muscle Builder
• Anabolic & Anti-Catabolic Properties
• Dramatic Body-Recomposition Benefits
• Increased Muscle Hardness & Definition
• Improved Endurance & Enhanced Recovery
• Maximizing Bone Morphogenic Protein (BMP) Levels

Multi-Action Muscle Building & Natural Anabolic Pathway Support: 

• Anabolic Properties
• Anti-Catabolic Properties
• mTOR Activation
• GLUT4 Expression
• Bone Health Support
• Immune System Support
• Increasing Bone Morphogenetic Protein (BMP) Levels
• Enhancing Bone Morphogenetic Protein (BMP) Signaling
• Enhancing Bone Morphogenetic Protein (BMP) Expression
• & Much More

Ask Yourself a Few Questions:

• Do you want to experience incredible lean muscle gains?
• Do you want hardcore strength gains?
• Do you want to enhance fat loss & improve body-composition?
• Would you like to improve recovery between sets & between workouts?
• Are you ready to experience a supplement that works in exciting new ways?

^^^ If you answered yes to any of the above questions, then meet your new workout partner, BASIS.

BASIS is designed to help you look better, feel better, and perform better (in more ways than one).

BASIS – Building A Solid Infrastructure

BASIS is a true multi-faceted natural anabolic muscle builder and recomposition catalyst that works through multiple pathways in order to help you reach your physique, strength, and athletic goals.

Structure

When you think of a structure, you likely think of a building. A building may be short, tall, big, or small – but no matter what the shape and size, it is only as solid as its foundation.

Infrastructure

When you think of infrastructure, most people likely think of roadways, communications systems, power grid, water systems – all of the things that are at the very heart and core of the basic operations of our society.

The actual definition is – the basic physical and organizational structures and facilities (buildings, roads, power supplies) needed for the operation of a society or an enterprise.

Most everyone has seen a movie in which the bad guys plan involves knocking out the infrastructure of somewhere so that it negatively impacts the population.

Building a Solid Infrastructure

With the above thoughts and definitions in mind, what is the foundation of the body?

The human body is made up primarily of bone and muscle tissue – they are the foundations of the human body in simplest terms.

Of course, this subject can get very deep and complex, and we could delve into the more advanced science of cells, hormones, neurotransmitters, etc. but that would be like breaking down the thought process of a buildings foundation to concrete, bricks, etc. All of these things come together to build a solid foundation, a solid structure, and contribute to a solid infrastructure.

Remember, if the foundation or infrastructure is weak, everything built on top of it is weak too.

B.A.S.I.S. – Not Just Another Average Natural Anabolic Muscle Builder

BASIS delivers a lot of muscle building potential from a lot of different angles.

BASIS covers a lot of the popular muscle building bases but is also designed to target optimal muscle growth by opening up a variety of new muscle building pathways.

Pathways to a Solid Infrastructure

The human body is in a constant state of muscle protein turnover, meaning that it is always breaking down and rebuilding muscle tissue, a process that is crucial for muscle growth and repair.

Anabolic Pathways – Maximizing Muscle Growth

The word anabolic is so overused that its easy to become desensitized to it and what it really means.

Here are some important definitions:

• Anabolic: Something that promotes anabolism.
• Anabolism: The metabolic process where the body builds and repairs muscle tissue.
• Anabolic State: The state in which the body is focused on building and repairing muscle tissue.

BASIS contains a variety of natural anabolic ingredients (ingredients that promote anabolism) in order to help you stay in an anabolic state (state in which the body is focused on building and repairing muscle tissue) as much as possible, by promoting anabolism (the process where the body builds and repairs muscle).

Anti-Catabolic Pathways – Minimizing Muscle Breakdown

A catabolic state is essentially the opposite of an anabolic state and is a state that you would prefer to avoid as much as possible if your goal is to gain or retain lean muscle.

BASIS contains multiple ingredients that have anti-catabolic properties to help you build and retain lean muscle tissue.

Here are some important definitions:

• Catabolic: Anything that promotes catabolism (the opposite of anabolism).
• Catabolism: The metabolic process in which your body breaks down muscle tissue to use as energy (the opposite of anabolism).
• Catabolic State: The state in which the body is breaking down or losing muscle tissue.
• Anti-Catabolic: Something that prevents or reduces the breakdown of proteins and muscle tissue in order to help retain muscle mass and promote recovery.

BASIS contains a variety of anti-catabolic ingredients (ingredients that help reduce the breakdown of muscle tissue) in order to help you stay out of a catabolic state (state in which your body is breaking down muscle tissue) as much as possible, in favor of an anabolic state (state in which your body is focused on building and repairing muscle tissue.

Immune System

The immune system is a complex system that helps the body fight off disease and infections in order to support optimal health.

Many people don’t think about the importance of a healthy immune system for supporting optimal muscle growth, but that can be a big mistake a lot of times.

Think about how long and hard you work to build lean muscle and strength gains, but then how quickly they can be lost during even a simple sickness or illness.

But it goes beyond that because the immune system may play an important role in lean muscle gains, exercise-related injuries and recovery, muscle loss, age-dependent muscle loss, & more.

BASIS contains ingredients to help support a healthy immune system for a strong muscle building foundation.

Bone Health

Bone health is of crucial importance for maximizing both lean muscle and strength gains.

Bone health can affect your results in the gym in the obvious way in that a broken bone can be detrimental to your process and keep you out of the gym for months or in some cases years.

And of course, strong bones are important for increased strength gains and injury prevention.

Years of hard fought for gains can disappear so quickly, yet many people never think about the importance of focusing on bone health as part of their foundation on which other gains are built upon.

Something very exciting about this is that there has been a lot of research in the last decade showing that some of the same growth factors that can influence bone health may also have major muscle building implications (more info below).

Senescent Cell Clearance

Senescent cells, also known as “zombie cells”, are cells that have stopped dividing but remain alive. They accumulate in the body and can release harmful substances that can contribute to aging, age-related health problems, and have detrimental effects on muscle, strength, endurance, and performance.

Muscle tissue is made up of a network of cells. These cells are constantly dividing and regenerating in order to maintain the health and function of the muscle tissue. However, at a certain point, these cells may stop regenerating and become senescent – which means that the cell is no longer a functioning part of the muscle tissue, but instead of ‘dying’ and being replaced by a healthy cell, it stays there taking up space where a healthy and contributing cell could be.

The higher the number of senescent cells in a tissue, the lower rate the tissue can perform.

To help you better understand senescence and the importance of senescent cell clearance in simple terms, think of it like defragging a computer or rebooting a phone – getting rid of the clutter and things that are slowing it down and making it not perform the way it is capable of:

• Analogy 1: Senescent cells are like old, fragmented files on your computer that have been left behind during previous tasks, causing your system to slow down and become less efficient. These files don’t contribute anything useful, but they’re still taking up space, slowing down overall performance. You defrag your computer to help speed up and optimize performance.
• Analogy 2: You could think of senescent cells as old apps running on your phone that drain the battery and take up space, slowing down performance. Improving senescent cell clearance would be like rebooting the phone, closing the apps, and letting the system reload fresh, new software to make it work better and more efficiently.

If you think back to our definitions and discussion on establishing a solid infrastructure, you can likely understand why promoting senescent cell clearance is an important part of a solid foundation.

Younger/newer muscle cells typically work harder and recover faster than older muscle cells because they have higher mitochondria counts, which may produce more energy and have greater ATP energy production capacity, leading to higher levels of cellular energy and endurance.

BASIS contains multiple ingredients that help support senescent cell clearance, including Senactiv®, the first senolytic sportsceutical that has been shown in studies to elevate exercise endurance, recovery, and energy while supporting senescent cell clearance and new muscle cell generation during high-intensity exercise.

By incorporating ingredients that have been shown in human clinical studies to support senescent cell clearance in muscle tissues, it helps lay the proper foundation for improved Bone Morphogenetic Protein (BMP) signaling, expression, and levels to deliver the best results.

Bone Morphogenic Proteins

Bone Morphogenic Proteins (BMPs) are a group of proteins within the Transforming Growth Factor beta (TGF-beta) super family of genes that have pivotal roles in the regulation of bone induction, maintenance, and repair. Originally discovered and researched for their ability to induce the formation of bone and cartilage, BMPs have now been found to constitute a group of morphogenetic signals that influence tissue architecture throughout the body.

Although Bone Morphogenic Protein (BMP) sounds like it would be specifically related to bones, it is not.

Research has shown that BMPS can play an important role in body-composition, both in building muscle and in reducing body-fat.

BASIS contains ingredients to help target key aspects of this exciting & complex system.

Bone Morphogenetic Proteins (BMPs) – A Better Understanding

When it comes to building muscle, losing fat, improving recovery, and recovering from injuries, there is so much going on inside our bodies that we can’t see with the naked eye.

A group of powerful proteins known as Bone Morphogenetic Proteins (BMPs) plays a crucial role in many of these processes. While BMPs were originally recognized for their role in bone formation and healing, newer research has shown that they can also promote muscle growth, improve fat metabolism, and speed up recovery.

What are Bone Morphogenetic Proteins (BMPs)?

Bone Morphogenetic Proteins (BMPs) are a group of growth factors that belong to a family of proteins called TGF-beta (transforming growth factor-beta).

While the name “Bone Morphogenetic” suggests their primary function is related to bones, these proteins are involved in more than just bone growth—they play significant roles in muscle tissue repair, fat metabolism, and healing after injury.

Bone Morphogenetic Proteins (BMPs) have been found to play a crucial role in muscle anabolism, promoting muscle growth and inhibiting muscle wasting.

In simple terms, BMPs act as ‘messengers’ that tell cells in our body how to behave. They help:

• Build and maintain bone tissue.
• Stimulate the formation of muscle cells and promote muscle repair.
• Influence the way the body stores and burns fat.
• Aid in tissue recovery after injury, both for bones and muscles.

Important definitions:

• BMP Signaling – refers to the process of how BMPs activate cellular responses through their receptors and intracellular signaling pathways.
• BMP Levels – refer to the actual concentration of BMPs, which can modulate the intensity or outcomes of BMP signaling.
• BMP Expression – refers to the genes activated by the signaling pathways.

While BMPs are involved in many processes in the body, their impact on muscle building, fat loss, and recovery is especially important for anyone looking to improve their fitness, health, or athletic performance.

Key BMP’s Involved in Muscle Growth, Fat Loss, & Recovery

There are over 20 different bone morphogenetic proteins, each with different roles in the body.

Some of the most important BMPs when it comes to building muscle, losing fat, and recovery are:

• BMP-2: BMP-2 is considered a potent growth factor that can significantly support enhanced bone regeneration by stimulating the differentiation of stem cells into osteoblasts (bone-forming cells) and promote new bone formation. In addition, research suggests that it can also play a key role in muscle growth and regeneration, potentially promoting muscle growth and inhibiting muscle wasting.
• BMP-4: While BMP-4 is primarily known for its role in bone development, it also plays a role in muscle building, particularly in regulating the proliferation and differentiation of satellite cells, which are the stem cells of adult skeletal muscle. It is also important for muscle repair and regeneration and some studies have shown that BMP-4 signaling may downregulate myostatin expression.
• BMP-7: BMP-7 plays an important role in muscle growth, with studies showing its ability to promote hypertrophy (muscle building) and to protect against atrophy (muscle wasting). It is known for its role in supporting healing in bones and tissues, and is involved in muscle regeneration, particularly after muscle injuries. It has been shown to stimulate the differentiation of myoblasts into mature cells, which is important for repairing damaged muscle fibers and helping to restore healthy muscle function. It may also help prevent fibrosis (scar tissue formation) during muscle tissue repair, which is significant because fibrosis can impede muscle regeneration and lead to loss of functionality. Studies have also shown that increasing BMP-7 signaling can increase fat oxidation and energy expenditure (burning calories).

With that in mind, let’s look at which ingredients in BASIS have been shown to increase the levels, signaling, or expression of:

• Icariin (Horny Goat Weed): BMP-2, BMP-4, and BMP-7
• Hwanggeumchal Sorghum Extract: BMP-7
• Naringin: BMP-2 and BMP-7 (indirectly)
• QuerceFit®: BMP-2 and BMP-7
• Kaempferol: BMP-2 and BMP-7
• Ligustrazine: BMP-2 and BMP-7
• Osthole: BMP-2 and BMP-7
• Apigenin: BMP-2 and BMP-7
• Salidroside: BMP-2 and BMP-7

Important Note:

It’s important to emphasize that even if you have taken some of these ingredients individually by themselves in the past, the real power is taking them together in order to effectively target the different BMP pathways together.

Let’s Examine the Ingredients

In the section above, we listed out which ingredients are thought to work via which Bone Morphogenetic Protein (BMP) pathways, but there’s great news – because as great as it is that BASIS works through key BMP pathways, there’s a lot more to BASIS!

Almost every ingredient in BASIS is included because it helps support building muscle &/or burning fat via more than one pathway, and in most cases, these pathways come together to compliment each other and help provide increased synergistic results!

Icariin (from Horny Goat Weed) (as HG20X™) – 500 mg. HGW/100 mg. Icariin

Icariin is derived from Horny Goat Weed (Epimedium). There are numerous standardizations available, but for the purposes of inclusion in BASIS, we selected the ultra-potent HG20X™ 20% Icariin extract.

This is a great example of an ingredient that has become so well-known for one subject or category that people often overlook any other potential benefits that it may have.

The Importance of Standardization (Icariin)

As with many herbs, it’s not the herb itself that provides the benefits, but the active constituent that the herb is standardized for.

The active constituent of Horny Goat Weed (Epimedium) that provides the benefits is Icariin.

The active ingredient related to the bone morphogenetic protein aspect is Icariin.

So what matters is the amount of Icariin in the product.

That’s why we use HG20X™, a Horny Goat Weed standardized for a minimum 20% Icariin.

Beware – Icariins and Icariin are Very Different

It is very important to distinguish between Icariin and Icariins, as the (s) at the end makes all the difference. You want Icariin without the (s) at the end, as it is Icariin that provides the benefits whereas Icariins do not.

Unfortunately, many Horny Goat Weed products on the market are not standardized at all or are standardized for Icariins, as that is a lot cheaper than being standardized for Icariin. This allows for brands to significantly cut product costs, but is deceptive towards consumers, as most consumers don’t know the difference and what they should be looking for.

Sexual Health & Libido

Icariin supports an increase in natural testosterone levels and libido/sex drive and has also been shown to support improved erection quality by acting as a natural PDE5 inhibitor, meaning that it may help inhibit the protein phosphodiesterase 5 enzyme that interferes with blood flow to the penis.

Enhanced Nitric Oxide/eNOS Production

Icariin has been shown to increase nitric oxide (NO) production by stimulating endothelial nitric oxide synthase (eNOS) and activating signaling pathways like PI3K/Akt. This plays a role in promoting blood flow and nutrient delivery to muscle tissues and can support improved muscle endurance, faster muscle recovery, and increased muscle fullness, pumps, and vascularity.

Icariin and Bone Morphogenetic Protein

Icariin is the main active flavonoid glucoside from the Chinese Epimedium herb, better known in some parts of the world as Horny Goat Weed. Epimedium has a long history of use in traditional Chinese medicine (TCM) for osteoporosis, osteoarthritis, and bone fractures.

Icariin has been shown in studies to have positive benefits on bone metabolism, including anti-osteoporosis, anti-osteoclastogenesis, and osteogenesis (the formation of bone).

Several studies have shown that Icariin can increase osteogenic differentiation and reduce bone loss in vivo and in vitro. Osteogenic differentiation is a crucial biological process for maintaining bone remodeling and fracture repair.

Important Reminder: Although Bone Morphogenic Protein (BMP) sounds like it would be specifically related to bones, researchers have found that BMP can be a limiting factor as to how much muscle growth one can achieve, making stimulating BMP an exciting new pathway to increasing muscle and strength and improving body-composition.

Studies have shown that icariin treatment increases the expression of BMP-2, BMP-4, and BMP-7.

The pathways through which Icariin has been shown to support BMPs include a variety of critical signaling pathways such as PPARγ, ERα/AKT/β-catenin, and MAPK, and many researchers believe that there are still a lot of underlying mechanisms that have yet to be fully understood.

Icariin has also been shown to promote BMP2 by activating the cAMP/PKA/CREB signaling axis pathway. Researchers then used a PKA selective inhibitor to inhibit the effect of Icariin on osteogenesis, thus reinforcing that Icariin was indeed having a stimulatory effect on BMP2 and osteogenesis.

Here is an excerpt from one study that confirms Icariin increases BMP-7, inhibits PDE5, and has promising potential for fat loss due to these mechanisms:

• Study: Icariin has the potential to induce the differentiation of bone marrow mesenchymal stem cells into brown fat cells via PDE5A inhibition
• Excerpt: Bone morphogenetic protein-7 (BMP-7) is reported to induce the PGC-1α and elevate the expression of UCP-1 and PPAR-γ to activate brown adipogenesis. In addition, the WAT browning is accompanied by UCP-1 upregulation, increasing the energy consumption, and attenuating the inflammatory response in adipose tissues.
• Conclusion: The results of this study demonstrated that ICA could induce the differentiation of BMMSCs into brown fat cells via PDE5A inhibition, suggesting that ICA may become the promising therapeutic agent for obesity related diseases.

In simple terms, this study demonstrates that:

• Icariin does increase BMP-7.
• Icariin does inhibit PDE5.
• Icariin is shown to have promising potential for fat loss.

In summary, Icariin is included in BASIS to help support an increase in BMP-2, BMP-4, and BMP-7 expression and levels, its potential role in increasing nitric oxide & eNOS, and for its natural PDE5 inhibition support benefits.

Hwanggeumchal Sorghum Extract – 500 mg.

Hwanggeumchal Sorghum Extract has been shown to enhance BMP-7 and Growth Hormone (GH) signaling through the activation of the Jak2/STAT5B pathway, a crucial pathway in GH signaling.

Growth Hormone (GH) has a well-established influential effect on bone growth, muscle mass, and body-composition. When GH levels are elevated, it triggers something called the Jak2/STAT pathway which regulates IGF-1, which is another major player in bone and muscle growth.

Hwanggeumchal sorghum extract has been shown to act almost exactly like Growth Hormone in activating the Jak2/STAT pathway, which then increases the expression of GH related proteins, the GH receptor, IGF-1, the IGF-1 receptor, and BMP7. This can help influence an optimal muscle building environment.

Hwanggeumchal Sorghum extract has also been the subject of some very interesting anti-aging and longevity research.

Naringin – 250 mg.

Naringin is a natural citrus bioflavonoid found in citrus fruits that has been researched for a wide variety of potential benefits. It has been shown in studies that it may have antioxidant, anti-inflammatory, cardioprotective, and neuroprotective benefits.

Naringin has been researched to see if it would help with metabolic syndrome, and was shown to support reducing blood pressure, glucose levels, and fasting insulin levels.

Naringin has also been shown to increase absorption of and the effects of some other ingredients.

Bone Morphogenetic Protein Research

Osteoporosis is the reduction in skeletal mass due to an imbalance between bone resorption and bone formation. Bone morphogenetic protein (BMP) plays an important role in osteoblastic differentiation and bone formation. Naringin has been researched for its role in BMP activation.

Bone and cartilage disorders are the leading causes of musculoskeletal disability. There is no cure for all of these disorders, so they are the subject of a great amount of research, including on natural compounds. Naringin has been researched due to its potential multifaceted activities in bone and cartilage tissue.

There has been an immense amount of information about Naringin learned from these studies.

It is important to note that the information in this write up is provided to show how Naringin may support an increase in bone morphogenetic protein levels and that no claims are being made about osteoporosis or bone or cartilage conditions. Any mention of osteoporosis &/or bone and cartilage conditions is only mentioned to provide the context of the study findings as they may relate to bone morphogenetic proteins.

Studies indicate that Naringin may promote osteogenic differentiation, inhibit osteoclast formation, and exhibit protective effects against osteoporosis and in bone and cartilage disorders in vivo and in vitro. Many signaling pathways, such as BMP-2, Wnt/β-catenin, and VEGF/VEGFR, participate in the biological actions of Naringin in mediating the pathological development of osteoporosis.

One study conclusion noted:

Further biological and pharmacological evaluations of naringin and its applications in bone tissue engineering, particularly its therapeutic effects against osteoporosis, might result in developing potential drug candidates.

Another study noted:

Our results provide evidence that Naringin increases BMP-2 expression and enhances osteogenic response via the phosphoinositide 3-kinase (PI3K), Akt, c-Fos/c-Jun and AP-1-dependent signaling pathway.

To Paraphrase on the Matter of Naringin and Bone Morphogenetic Protein: 

Naringin has been shown in studies to support increases in mRNA and BMP-2 levels and to help reduce the decreasing of BMP-2 and bone loss.

Quercefit® – 250 Mg.

Quercetin is a natural flavonoid compound widely found in vegetables, fruits, and nuts. A great number of important biological activities of quercetin have been discovered in recent years, therefore interest in potential quercetin benefits on human health has rapidly grown.

One hurdle with Quercetin supplementation has always been that due to poor oral bioavailability, a high daily dosage has generally been needed to achieve desired results.

Quercefit® is a specialized Phytosomal form of Quercetin that possesses optimized absorption and is up to 20x more bioavailable than regular Quercetin supplements.

Immune Support

Quercefit® has been shown in clinical studies to help maintain immune system health and modulate cytokine cascades due to its senolytic function.

Physical Performance

Quercefit® has been shown in studies to support optimal physical performance and promote improved recovery. In one study on triathlon athletes, Quercefit® was shown to optimize training and performance and a leveling of oxidative stress.

Body-Composition

Quercefit® has shown muscle building and fat loss properties, especially when used with whey protein. One study showed significant abdominal fat loss, visceral fat loss, subcutaneous fat loss, and a reduced waist circumference.

Bone Morphogenetic Protein

Quercetin supports an increase in the expression of BMP-2, the upregulation of BMP-7, and the enhancement of overall BMP signaling.

Allergies

Quercetin has been widely studied for its potential allergy benefits. As positive as the results have been, a holdback for many people has always been that the poor oral bioavailability meant having to use very high dosages (a lot of capsules per day) to see potential allergy related benefits.

As a form of Quercetin with greatly enhanced oral bioavailability, Quercefit® packs all of the benefits of Quercetin for allergy suffers at a much lower dosage.

Kaempferol Cyclodextrin Complex – 200 Mg.

Kaempferol is a naturally occurring flavanol found in plants that has a wide variety of potential general health and physique enhancing benefits.

Here are some of the things that Kaempferol may support:

• Fat Loss: Research suggests that Kaempferol may support fat loss by promoting fatty acid oxidation, inhibiting lipogenesis, and supporting the browning of white fat.
• ATP Production: Studies suggest that Kaempferol may support an increase in ATP production, possibly by multiple mechanisms.
• Mitochondrial Health: Mitochondria are the powerhouses of cells. Kaempferol may improve mitochondrial function, which can enhance energy production and muscle function.
• Cardiovascular Support: Kaempferol may support improved cardiovascular and endothelial health by helping to protect blood vessels from damage induced by oxidative stress & inflammation.
• Cognitive Support: Kaempferol has been shown to have potential cognitive support and neuroprotective support benefits.
• Cardiopulmonary Load Reduction: Studies suggest that kaempferol can reduce cardiopulmonary load and muscular damage during repeated high-intensity exercise, such as 400-meter sprints.
• Improved Muscle Glucose Uptake: Kaempferol has been shown to stimulate glycose uptake in skeletal muscle cells, which is important for providing fuel for muscle activity.

Bone Morphogenetic Protein

Kaempferol has been shown to increase BMP-2 and BMP-7 expression, likely by activating the ERK/BMP-2 signaling pathways, which increases the expression of BMP-2 and BMP-7. These BMPs are involved in tissue regeneration and repair, including muscle tissue. By promoting the differentiation and regeneration of muscle cells, Kaempferol could aid in muscle recovery and muscle growth.

Kaempferol has been found to activate several intracellular signaling pathways that regulate gene expression. For example, research suggests that Kaempferol can upregulate MAPK signaling pathways, which can regulate BMP signaling, and which play a crucial role in regulating various cellular processes, including muscle growth and metabolism.

Kaempferol induced autophagy (a cellular process that removes damaged components) may also contribute to osteoblast differentiation and help maintain healthy muscle cells, further supporting muscle building efforts. (This ties in with the Apigenin and Senactiv® as well).

Ligusticum Wallichii Extract (98% Ligustrazine) – Soy Free – 200 Mg.

Ligustrazine is a natural compound found in the roots of the Asian plant Ligusticum Wallichii.

Ligustrazine has potential anti-inflammatory and nootropic benefits, but for the purpose of this write up we are focused on its potential muscle building and muscle sparing benefits.

Ligustrazine has been shown to support the elevation of BMP-7, a potent anti-inflammatory growth factor. It is also thought to support a reduction in the activity of the catabolic signal molecule MuRF1 and has been shown in multiple studies to reduce the amount of muscle loss as compared to control groups, in both short-term and longer-term studies.

Ligustrazine has also been shown to support an increase in glucose uptake to muscle cells and to help protect against the oxidative damage from both high fat and high sugar diets. It has also been shown to support an increase in fatty acid utilization. This not only may increase fat burning but may also spare glucose to be used in the muscle cells to preserve energy & muscle mass.

Ligustrazine has even been shown to support improved mitochondrial biogenesis.

Osthole Cyclodextrin Complex – 200 mg.

Osthole is a dietary supplement ingredient that has been used to support cardiovascular health, cognitive health, liver health, vasodilation, optimal hormone levels, and has natural PDE5 inhibition properties.

Natural PDE5 Inhibition Properties

Cnidium Monnieri, the herb that Osthole is derived from, and Osthole itself, have both been shown in research to have PDE5 inhibitor properties. Phosphodiesterase 5 (PDE5) is an enzyme that plays a role in the breakdown of cGMP, a molecule that helps relax smooth muscles in the penis, allowing for blood flow and helping to achieve and maintain erections.

Bone Morphogenetic Protein Properties

Osthole has been shown to increase BMP-2 and BMP-7 expression, support the activation of Wnt/beta-catenin signaling, and induce osteoblast differentiation.

Apigenin (as ApiPure™) – 100 Mg.

Apigenin is an exciting natural muscle building, general health, healthy aging, & longevity phytonutrient.

Apigenin is a natural flavonoid found in parsley, celery, chamomile, and citrus fruits and is similar to Quercetin, Hesperidin, Luteolin, and Kaempferol. However, even though its structure is very similar to these compounds, Apigenin has some very different effects in the body than those related substances.

Apigenin has a natural anabolic effect, as first discovered by researchers at the Korea Food Research Institute. Researchers found that it has the unique ability to inhibit 17β-hydroxysteroid dehydrogenase (17β-HSD) and animal studies have shown it to support muscle protein synthesis and muscle growth via increased phosphorylation of several key players in the mTOR pathway including Akt, S6K1, & 4E-BP1.

In the initial study that led to Apigenin’s popularity for building muscle, scientists began experimenting with this flavone with mice and the mice receiving the Apigenin had significant muscle mass gains over the mice not receiving it. The greater the dosage of Apigenin the mice took, the larger the quad increase!

Even before the research showing its natural anabolic benefits, Apigenin was already regarded as a very exciting compound due to its wide variety of overall health benefits including its anti-inflammatory benefits as well as its potential prostate, neuroprotective, and cardioprotective properties.

Another very exciting aspect of Apigenin is its ability to enhance autophagy. Autophagy is a natural cellular mechanism by which by which the cells in our body degrade unnecessary or damaged components within the cell. The process of autophagy helps maintain normal functioning (homeostasis) in the cell (think back to the defragging a computer analogy in the senescence section).

Apigenin & Bone Morphogenetic Proteins (BMPs)

Apigenin has been shown to influence several biological pathways, including Bone Morphogenetic Protein (BMP) levels, signaling, and expression.

Activation of BMP Pathways

Apigenin has been shown to support the activation of BMP signaling pathways, likely through the upregulation of BMP receptors and ligands. Apigenin can influence the modulation of the expression of genes involved in BMP signaling, possibly by affecting transcription factors or intracellular signaling molecules that regulate these processes.

Modulation of Gene Expression

Apigenin may influence the expression of BMP-related genes. For instance, studies have shown that Apigenin may upregulate the expression of BMP-2 and BMP-4. This upregulation can occur via the activation of transcription factors, such as SMAD proteins, which are key mediators in the BMP signaling cascade.

BMP Receptor Activity

BMP receptors play a central role in the activation of the BMP signaling pathway. Apigenin may enhance the sensitivity of cells to BMP signaling by increasing the expression or activity of these receptors, facilitating the downstream effects of BMP signaling, which could lead to a stronger activation of the pathway.

SMAD Pathway Activation

The SMAD signaling pathway is one of the downstream effects of BMP receptor activation. Apigenin can promote the activation of SMAD1/5/8 phosphorylation, which then translocates to the nucleus to regulate the transcription of target genes involved in bone formation. This suggests that apigenin may enhance BMP-mediated osteogenesis by activating the SMAD pathway.

Inhibition of Negative Regulators

Apigenin may also support an increase in BMP signaling by inhibiting negative regulators such as Noggin and Chordin, which both act to suppress BMP activity. By supporting a reduction in the expression of these inhibitors, Apigenin may promote a more robust BMP signaling response.

Osteogenesis Enhancement Support

Apigenin has been noted to support the enhancement of osteogenic differentiation in mesenchymal stem cells (MSCs). This is likely due to the combined effects of increasing BMP signaling and promoting the expression of osteogenic markers, which are crucial for bone formation and regeneration.

In summary, Apigenin likely supports an increase in BMP levels, signaling, and expression through a combination of mechanisms, including enhancing the activity of BMP receptors, promoting the transcription of BMP-related genes, and activating downstream signaling pathways.

Senactiv® – 50 Mg.

Senactiv® is the first senolytic sportsceutical that elevates exercise endurance, recovery, and energy while supporting senescent cell clearance and new muscle cell generation.

Senactiv® is a natural, patented, plant-based nutraceutical that has been scientifically validated in human studies and in in-vivo studies and has been shown to promote increased muscle energy and preservation via senescent cell clearance. This means that it aids in the removal of old cells and replenishment with new healthy muscle cells.

Senactiv® also increases the production of citrate synthase, an important enzyme that is responsible for producing more ATP (energy our body uses).

Senactiv Highlights/Supports:

• Exercise Endurance: Senactiv® helps your body clear out senescent cells, allowing for the generation of younger, more efficient muscle cells with higher energy production capacity. In a human clinical trial published in the esteemed PLOS One, Senactiv® was shown to increase endurance time (time to exhaustion) by 20% in a high-intensity (89% V02 max) cycling exercise.
• ATP Production: Senactiv® has been shown to increase ATP production by enhancing citrate synthase by up to 47%.
• Muscle Energy: Senactiv® promotes the generation of muscle cells with a higher number of mitochondria, the “powerhouses” of cells, resulting in increased energy production during exercise.
• Faster Recovery: Senactiv® supports improved recovery by activating the body’s cellular processes to clear out senescent cells (old, damaged cells) in muscles, allowing for the generation of new, healthy muscle cells which can perform better and recover faster.
• Muscle Cell Renewal/Regeneration: Senactiv® supports muscle cell renewal and regeneration by helping to eliminate senescent cells and promoting new muscle growth.
• Muscle Preservation: Senactiv® has been shown in human clinical studies to support muscle preservation by clearing senescent cells and reducing inflammation.

How does Senactiv work? 

Muscle tissue is made up of a network of cells. These cells are constantly dividing and regenerating in order to maintain the health and function of the muscle tissue. However, at a certain point, these cells may stop regenerating and become senescent – which means that the cell is no longer a functioning part of the muscle tissue, but instead of ‘dying’ and being replaced by a healthy cell, it stays there taking up space where a healthy and contributing cell could be. The higher the number of senescent cells in a tissue, the lower rate the tissue can perform.

Younger/newer muscle cells typically work harder and recover faster than older muscle cells because they have higher mitochondria counts, which may produce more energy and have greater ATP energy production capacity, leading to higher levels of cellular energy and endurance.

Senactiv® has also been shown in human clinical studies to support ATP production via enhancing the activity of citrate synthase by up to 47%!

How does boosting citrate synthase improve performance and increase ATP levels?

Boosting citrate synthase increases muscle energy by enhancing the rate of the Krebs cycle within the mitochondria, which is the primary pathway for generating ATP (cellular energy) from nutrients. Essentially, increasing citrate synthase means more efficient energy production within the muscle cell.

Senactiv® is the first senolytic for enhanced exercise performance and endurance on the market.

Salidroside (as SalidroPure™) – 25 mg.

Salidroside is most commonly known for being a constituent of Rhodiola Crenulata, which has been used for centuries for its anti-stress and anti-fatigue benefits as well as its mood-enhancing properties.

Endurance & Physical Performance

Salidroside is an adaptogen that helps the body cope with both physical and mental stress while supporting an increase in overall endurance and performance. This powerful compound helps increase the body’s resistance to fatigue, helping you to maintain higher levels of physical exertion for longer periods of time.

Mental Performance

Salidroside supports enhanced mental clarity and cognitive function, helping you to stay sharp and focused throughout the day, whether you’re in the gym, training for sport, or managing a demanding schedule.

Bone Morphogenetic Protein (BMP)

Salidroside has been shown to support Bone Morphogenetic Protein (BMP) signaling and expression.

Salidroside has been studied for and shown positive effects on bone anabolism. In one study, researchers found that Salidroside increased the mRNA level of genes controlling the BMP pathway and supported the elevation of BMP2 and BMP7 as well as SMAD1, 5, & 8. A second study, by a different set of researchers, confirmed these results.

The SalidroPure™ Advantage

Salidroside was originally only available in lower dosages because it had to be standardized from Rhodiola, and most normal Rhodiola only contained 1% Salidroside, meaning that a typical 300 mg. serving of Rhodiola would only give you 3 mg. Salidroside.

SalidroPure™ represents the evolution of Salidroside supplementation, especially for performance enhancement, by providing a much higher concentration that allows for much higher dosing and the ultimate in consistent potency so that you can feel and perform your best.

With SalidroPure™, you can now harness the power of highly dosed pure Salidroside to help take your endurance, focus, and overall performance to the next level.

BASIS contains an ultra-potent dose of 25 mg. SalidroPure™ per serving.

AstraGin® – 25 Mg.

AstraGin® is a natural patented ingredient complex comprised of highly fractionated Astragalus membranaceus and Panax notoginseng and created using pharmaceutical grade extraction and processing technology and designed to help enhance nutrient absorption

AstraGin® has been shown to help increase the bioavailability and absorption of a variety of key nutrients and may also support improved muscle recovery and growth following training as studies on ginsenosides (one of the key active constituents in AstraGin®) note that it activates the mTOR signal pathway by regulating upstream kinases in muscle cells.

AstraGin® is a perfect ingredient in the super comprehensive BASIS formula to help make sure that you properly absorb the other great nutrients in BASIS for maximum results and also for its potential mTOR signaling benefits.

Bioperine® – (10 Mg.)

Bioperine® is a standardized extract from the fruit of Piper nigrum L (Black Pepper) containing 95% piperine. Piperine has been shown to enhance the oral bioavailability of many ingredients.

Stacking & Synergy

BASIS can be stacked with M-Test, Anabolic Effect, Alpha One, Cloma-Plex, Cordarine (coming soon), Super Swole, Epi-Plex, LipoVantage, Lipo Elite, or or select other CEL products for even more hardcore results.

BASIS – More than Just a Bone Morphogenetic Protein (BMP) Product

As much of an emphasis that has been placed on Bone Morphogenetic Proteins (BMPs) in this write up, its important to emphasize that there is a lot more to BASIS than just that aspect.

BASIS stands for Building a Solid Infrastructure, and that’s what BASIS does – it focuses not only on increasing the levels, expression, and signaling of specific key BMPs, but on helping provide the groundwork and a solid foundation and the ideal circumstances for them to deliver optimal results.